Physician Wholesale Program

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Clinical Use Cases

  • Cognitive Decline

    Iso-Alpha’s hop-derived bitter acids support healthy neurotransmitter balance, enhance brain plasticity, and protect against age-related cognitive decline—shown in studies to rival the effects of leading Alzheimer’s drugs.

  • Neuroinflammation

    By activating bitter receptors in the gut and stimulating the vagus nerve, Iso-Alpha helps regulate immune signals in the brain—calming microglial overactivation and reducing neuroinflammatory load.

  • Memory Loss

    Iso-Alpha increases dopamine in the hippocampus, directly enhancing spatial and object-recognition memory. Backed by clinical data, its effects are both fast-acting and long-lasting.

  • Chronic Stress Overload

    By engaging the gut-brain axis and vagus nerve, Iso-Alpha helps shift the body out of sympathetic overdrive—reducing the physiological burden of chronic stress and improving mood resilience.

  • Insulin Sensitivity

    Iso-Alpha activates GLP-1 and other gut hormones through bitter receptor pathways, supporting blood sugar regulation, insulin sensitivity, and satiety signaling.

  • Gray Matter Atrophy

    Human trials show that supplementation with Iso-Alpha’s active compounds promotes gray matter growth in the posterior cingulate cortex—critical for attention, focus, and memory retention.
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Grey Matter Regeneration

Fukuda et al. (2020) in the Journal of Alzheimer’s Disease.

Here's a data visualization illustrating the increase in gray matter volume in the left posterior cingulate cortex following iso-alpha acid supplementation, based on human MRI data. This area of the brain is vital for memory integration, attention, and internal thought processing.

Vagus nerve stimulation

Hop-Derived Iso-α-Acids Improve Cognitive Function and Emotional Resilience via Vagal Stimulation: A Randomized Controlled Trial

Iso-Alpha Acids, have been shown to improve mood, reduce anxiety, and enhance cognitive performance in older adults with subjective cognitive decline. It also increased heart rate variability (HRV), indicating stronger vagal tone and better autonomic regulation.

Boosts Dopamine

Iso-Alpha, rich in iso-α-acids, has been shown to boost dopamine levels in the hippocampus through vagus nerve activation—leading to measurable improvements in memory and cognition. In studies, it reversed cognitive decline as effectively as donepezil, a top Alzheimer’s drug.

Hacking the Gut/Brain Connection

  • STEP 1: Gut

    The extremely bitter-tasting iso-alpha acids in Iso-Alpha act on the Bitter Taste Receptors in the gut.

  • STEP 2: Vagus Nerve

    The gut hormone CCK stimulates the vagus nerve - the connection between the gut and the brain.

  • STEP 3: Brain

    The vagus nerve signals the brain to release more acetylcholine, norepinephrine, and dopamine.
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