Power up your brain...
without jitters!
Over 40 scientific studies show that the main ingredient in iso-Alpha improves:
Focus
Mood
Learning
Motivation
Creativity
Memory
Slower is Actually Better!
Most nootropics use caffeine to snap your brain to attention... and it quickly wears off. But iso-Alpha permanently upgrades cognitive function - in just 90 days!
Enlightenment...in a Pill?
Since the dawn of human history shamans, monks, artists, and bio-hackers have been infatuated with practices that unlok "enlightened" montal states...
Cold Showers
Deep Breathing
Yoga Postures
What do these practices have in common?
They stimulate the vagus nerve - which signals the brain to release "happy chemicals" that unleash creativity, help you focus, and make you feel good.
Over 80 medical studies show that iso-alpha acids(IAAs) found in the hops plant can stimulate the vagus nerve in a very similar way.
Now you can upgrade your brain in seconds a day... no yoga mat required!
Hacking the Gut/Brain Connection
STEP 1: GUT
Insert the Key
The extremely bitter-tasting iso-alpha acids in iso-Alpha act on the Bitter Taste Receptors in the gut.
STEP 2: VAGUS NERVE
Send The Signal
The gut hormone CCK stimulates the vagus nerve - the connection between the gut and the brain.
STEP 3: BRAIN
Open the Gate
The vagus nerve signals the brain to release more acetylcholine, norepinephrine, and dopamine.
Special Pricing For First-Time Customers!
TRY ISO-ALPHA
Opens the Flood Gates to More...
Learning with Acetylcholine
A chill brain is a happy brain - and acetylcholine relaxes your body and brain to prime them for learing.
Focus
Learning
Mood
Memory
Concentration with Norepinephrine
When it's time to mobilize the brain to action, your nervous system needs norepinephrine - deficiencies are linked to depression and ADHD.
Energy
Focus
Learning
Mood
Success with Dopamine
he would (and your brain) runs on dopamine - it's the neurotransmitter that helps your think, strive, plan, and achieve.
Mood
Creativity
Mood
Motivation
One Ingredient
with many health benefits!
The IAAs in hops aren't limited to the brain - over 80 medical studies cover a number of medical issues including...
Energy
Inflammation
Joint Pain
Insulin Resistance
Metabolism
Leaky Gut
Supplement Facts
Serving Size 1 capsule
Serving Per Container 30
Amount per Serving
Hops Isohumulone 100mg
Daily Value not Established
Contains: oleic, linoleic and stearic fatty acids and essential oils.
OTHER INGREDIENTS:
Polyoxyl Castor oil and hydroxypropylmethyl-cellulose(vegetable capsule), patented Hops Isohumulone and favonoid (polyphenol) formula.
EXCLUSIVE PATENTED BIOAVAILABLE HOPS FORMULATION
*If pregnant or nursing or have a serious medical condition consult your doctor before use.
You might be wondering...
"Aren't There Hops in Beer?"
Since iso-alpha acids (IAAs) are extracted from hops - the plant used to make beer - you're probably wondering if you can drink your way to enlightenment.
Well just so you know... In order to consume the 100mgs that are in a single capsule of iso-Alpha, you would have to down several six packs of the bitterest IPA beer.
Now, before you attempt that experiment - let me just tell you that we've already tried, and it definitely did NOT help us get more done at our desk. :-)
And before you try to order a big bulk sack of hops cones, you should know that eating hops doesn't work either.
That's why we've patented a new way to extract that IAAs hiding inside hop resin, and put them in a bioavailable capsule you take just once a day.
Special Pricing For First-Time Customers!
TRY ISO-ALPHAUpgrade Your Brain ...in Just 90 Days!
Memory Processing
Attention Control
Verbal Skills
Gratification
Mental Endurance
Cognitive Flexibility
Perceptual Learning
Executive Function
Spatial Memory
Special Pricing For First-Time Customers!
TRY ISO-ALPHA90 Day "Brain Boost"
GUARANTEE
Use iso-Alpha every day for 90 days - and if you don't notice an impressive lift in your cognitive abilities - we'll gladly refund what you paid for our products!
Micah Lowe
Founder and CEO
iso-Alpha
Special Intro Pricing
This is your best chance to try iso-Alpha!
Medical Studies
- Livingston, G.;Sommerlad, A.; Orgeta, V.;Costafreda, S.G.; Huntley, J.; Ames, D.; Ballard, C.; Banerjee, S.; Burns, A.; Cohen-Mansfield, J. Dementia prevention, intervention, and care. Lancet 2017, 390, 2673–2734. [CrossRef]
- Neafsey, E.J.; Collins, M.A. Moderate alcohol consumption and cognitive risk.Neuropsychiatr. Dis. Treat.2011, 7, 465–484. [CrossRef] [PubMed]
- Xu, W.; Wang, H.; Wan, Y.; Tan, C.; Li, J.; Tan, L.; Yu, J.T. Alcohol consumption and dementia risk: A dose-response meta-analysis of prospective studies. Eur. J. Epidemiol. 2017, 32, 31–42. [CrossRef] [PubMed]
- Bastianetto, S.; Menard, C.; Quirion, R. Neuroprotective action of resveratrol.Biochim. Biophys. Acta 2015, 1852, 1195–1201. [CrossRef] [PubMed]
- Turner, R.S.; Thomas, R.G.; Craft, S.; van Dyck, C.H.; Mintzer, J.; Reynolds, B.A.; Brewer, J.B.; Rissman, R.A.; Raman, R.; Aisen, P.S. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology 2015, 85, 1383–1391. [CrossRef]
- Sawda, C.; Moussa, C.; Turner, R.S. Resveratrol for Alzheimer’s disease.Ann. N. Y. Acad. Sci.2017, 1403, 142–149. [CrossRef]
- Biendl, M.;Pinzl, C. Hops and health.MBAA TQ 2009, 46, 1–7. [CrossRef] CrossRef] Biomolecules 2020, 10, 131 11 of 15
- Milligan, S.R.; Kalita, J.C.;Heyerick, A.; Rong, H.; De Cooman, L.; DeKeukeleire, D. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J. Clin. Endocrinol. Metab. 1999, 84, 2249–2252.
- Stulikova, K.; Karabin, M.; Nespor, J.; Dostalek, P. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules 2018, 23, 660. [CrossRef]
- Liu, M.; Hansen, P.E.; Wang, G.; Qiu, L.; Dong, J.; Yin, H.; Qian, Z.; Yang, M.; Miao, J. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules 2015, 20, 754–779. [CrossRef]
- Intelmann, D.;Batram, C.; Kuhn, C.; Haseleu, G.; Meyerhof, W.; Hofmann, T. Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer. Chemosens. Percept. 2009, 2, 118–132. [CrossRef]
- Kowaka, M.; Kokubo, E. Composition of bitter substances of hops and characteristics of beer bitterness. Am. Soc. Brew. Chem.1977,35, 16–21. [CrossRef]
- Kunimune, T.; Shellhammer, T.H. Foam-stabilizing effects and cling formation patterns of iso-alpha-acids and reduced iso-alpha-acids in lager beer. J. Agric. Food Chem. 2008, 56, 8629–8634. [CrossRef]
- Simpson,W.J.; Smith, A.R. Factors affecting antibacterial activity of hop compounds and their derivatives. Appl.Bacteriol.1992, 72, 327–334. [CrossRef]
- Schurr, B.C.; Hahne, H.; Kuster, B.; Behr, J.; Vogel, R.F. Molecular mechanisms behind the antimicrobial activity of hop iso-alpha-acids in Lactobacillus brevis. Food Microbiol. 2015, 46, 553–563. [CrossRef]
- Taniguchi, Y.;Matsukura, Y.; Taniguchi, H.; Koizumi, H.; Katayama, M. Development of preparative and analytical methods of the hop bitter acid oxide fraction and chemical properties of its components. Biosci. Biotechnol. Biochem. 2015, 79, 1684–1694. [CrossRef]
- Biessels, G.J.;Staekenborg, S.; Brunner, E.; Brayne, C.; Scheltens, P. Risk of dementia in diabetes mellitus: A systematic review. Lancet Neurol. 2006, 5, 64–74. [CrossRef]
- Gudala, K.; Bansal, D.; Schifano, F.; Bhansali, A. Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. J. Diabetes Investig. 2013, 4, 640–650. [CrossRef]
- Xu,W.; Atti, A.; Gatz, M.; Pedersen, N.; Johansson, B.;Fratiglioni, L. Midlife overweight and obesity increase late-life dementia risk: A population-based twin study. Neurology 2011, 76, 1568–1574. [CrossRef]
- Waldstein, S.; Katzel, L. Interactive relations of central versus total obesity and blood pressure to cognitive function. Int. J. Obes. 2006, 30, 201. [CrossRef]
- Raji, C.A.; Ho, A.J.;Parikshak, N.N.; Becker, J.T.; Lopez, O.L.; Kuller, L.H.; Hua, X.; Leow, A.D.; Toga, A.W.; Thompson, P.M. Brain structure and obesity. Hum. Brain Mapp. 2010, 31, 353–364. [CrossRef]
- Spencer, S.J.; D’Angelo, H.; Soch, A.; Watkins, L.R.; Maier, S.F.; Barrientos, R.M. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal-and amygdalar-dependent memory. Neurobiol. Aging 2017, 58, 88–101. [CrossRef]
- Yajima, H.;Ikeshima, E.; Shiraki, M.; Kanaya, T.; Fujiwara, D.; Odai, H.;Tsuboyama-Kasaoka, N.; Ezaki, O.; Oikawa, S.; Kondo, K. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. J. Biol. Chem. 2004, 279, 33456–33462. [CrossRef]
- Gross, B.; Pawlak, M.; Lefebvre, P.;Staels, B. PPARs in obesity-induced T2DM,dyslipidaemia and NAFLD. Nat. Rev. Endocrinol. 2017, 13, 36–49. [CrossRef]