GLP-1: More Than a Blood Sugar Hormone
You might know GLP-1 (Glucagon-Like Peptide-1) from the headlines—it’s the hormone targeted by drugs like Ozempic. But GLP-1 is so much more than a metabolic hormone.
It’s a neuroprotective, anti-inflammatory, and gut-brain signaling molecule that helps regulate:
- Cognitive performance
- Neuronal repair
- Inflammation in the gut and brain
- Vagal nerve activity
And yes—it can be supported naturally.
Top Natural GLP-1 Activators for Whole-Body Support
1. Berberine and Bitter Botanicals
These compounds activate bitter taste receptors in the gut, which are closely tied to GLP-1 secretion. They’re often used for gut lining support and systemic inflammation.
Berberine and GLP-1
2. Capsaicin
Known for its “heat,” capsaicin has been shown to stimulate GLP-1 secretion via TRPV1 receptor activation in intestinal L-cells.
Capsaicin and GLP-1
3. Curcumin & Ginger
While not direct GLP-1 agonists, both have demonstrated supportive roles in modulating inflammation and enhancing gut peptide signaling.
Curcumin and metabolic peptides
4. Hops-Derived Iso-Alpha Acids — The Missing Link
Iso-Alpha acids from hops are bitter compounds studied for their effects on:
- GLP-1 secretion via gut T2R activation
- CCK (Cholecystokinin) stimulation—critical for vagus nerve signaling
- Neuroprotection, improved cerebral blood flow, and inflammation reduction
Hop-derived bitter acids & GLP-1
Iso-alpha acids and brain health
Unlike many supplements, this doesn’t rely on nutrient stacking. It uses direct gut signaling through bitter taste receptors to engage your body’s own systems.
Why Delivery Matters
Not all hops extracts are created equal. Iso-Alpha uses a patented extraction and delivery method, developed by PhD biochemist Eric Khurts, that ensures these bitter acids are actually absorbed—and biologically active.
In Summary
GLP-1 isn’t just a trendy target for pharma—it’s a powerful hormone tied to inflammation, brain performance, and gut-brain communication.
Natural activators like bitter hops acids are finally getting the spotlight for their ability to support these systems—without synthetic drugs.
Curious how it works in your body?
Learn more about Iso-Alpha →